多肽定制服務說明書
多肽介紹
多肽是氨基酸以肽鍵連接在一起形成的化合物，具有多種生物學功能，例如抗血栓形成、抗高血壓、抗菌、抗病毒、抗癌、抗氧化、免疫調(diào)節(jié)、降膽固醇等，目前已廣泛用于功能分析、抗體研究、疫苗開發(fā)及藥物研發(fā)等領(lǐng)域。
MCE 配備強大的技術(shù)人才團隊和國際先進的設備，提供全方位的高質(zhì)量定制肽服務，包括快速肽合成、標準化學肽合成、肽修飾、肽庫和重組多肽表達，以滿足生物與藥物發(fā)現(xiàn)研究中不斷增長的多肽需求。
■可選規(guī)格： 毫克（mg）級至公斤（kg）級。
■純度范圍： 粗肽、脫鹽、70% 至 98%。
■廣泛修飾： 可提供酰胺化、乙�；⒓谆⒘姿峄�、標記及偶聯(lián)等 300+ 種不同 修飾。
■合成技術(shù)： 結(jié)合固相合成及液相合成，微波和連接技術(shù)。
■免費咨詢： 專業(yè)的 MCE 技術(shù)團隊為您解答多肽定制的售前與售后的技術(shù)問題。
■ N 端修飾
| •Ac |
| •Allyl |
| •Cholesteryl- |
| •N-Propargylglycine- |
| •Fmoc |
| •Acryl |
| •Fructose- |
| •Ad |
| •CBZ |
| •Alloc |
| •Glucose- |
| •BPS- |
| •Boc |
| •Pyr |
| •Morpholine-4-carbonyl- |
| •Bz |
| •D-Pyr |
| •NTriAc |
| •Trans-Cinnamoyl |
| •Bz (5-NH2,2-NO2) |
| •LA- |
| •PhAc |
| •2-Furoyl |
| •Bz (4-F) |
| •Mpa- |
| •Py-Ac |
| •Methacryl- |
| •Bz (4-NO2) |
| •Tos |
| •N-Amidinoglycine |
| •BPA- |
■ C 端修飾
| •-pNA |
| •-OMe |
| •-ONP |
| •-OSu |
| •-NH2 |
| •-OEt |
| •-AMC |
| •-NHMe |
| •-ol |
| •-OBzl |
| •-AFC |
| •-NHEt |
■ 脂肪酸化
| •For |
| •MeOSuc |
| •5-Hexynoic acid |
| •F-Lau- |
| •MeOCO |
| •Iba |
| •Heptanedioic acid |
| •Myr- |
| •2-Br-Ac |
| •pentenoic acid |
| •Oct- |
| •F-Myr- |
| •2-Cl-Ac |
| •pentinoyl |
| •F-Oct- |
| •Pentadeconyl- |
| •2-I-Ac |
| •Hex- |
| •Dec- |
| •Pal- |
| •OH-Ac |
| •5-heptenoic acid |
| •Sebacic acid |
| •Cys (Pal) |
| •3-Bromopropionyl |
| •Trans-3-hexenoyl- |
| •F-Dec- |
| •Pam3C- |
| •But- |
| •Linoletic- |
| •Undecyl- |
| •Ste- |
| •Suc |
| •10,12-Pentacosadiynoic acid |
| •Lau- |
| •Octanedioic acid |
■ 甲基化
| •Lys (Me) |
| •Arg (Me) |
| •Tyr (Me) |
| •Tyr (Et) |
| •Lys (Me2) |
| •Arg (Me2)asymmetrical |
| •Thr (Me) |
| •D-Tyr (Et) |
| •Lys (Me3) |
| •Arg (Me2) symmetrical |
| •Ser (Me) |
■ 磷酸化
| •pSer |
| •D-pSer |
| •Di-sites in sequence |
| •4-sites in sequence |
| •pTyr |
| •D-pTyr |
| •Tri-sites in sequence |
| •5-sites in sequence |
| •pThr |
| •D-pThr |
■ 支肽
| •Symmetric 2 Branches |
| •Symmetric 4 Branches |
| •Symmetric 8 Branches |
| •Lys symmetric 2 Branches |
| •Lys symmetric 4 Branches |
| •Lys symmetric 8 Branches |
| •Orn symmetric 2 Branches |
| •Orn symmetric 4 Branches |
| •Orn symmetric 8 Branches |
| •Glu 2 Branches (Pure) |
| •Glycerol 3 Branches ester |
| •Thr (Peptide2) |
| •Ser (Peptide2) |
| •Lys (Peptide2) |
■ 環(huán)肽
| •Mono Disulfide bridge |
| •Double Disulfide bridge |
| •Triple Disulfide bridge |
| •Random Triple Disulfide bridge |
| •Same Sequence Inter-Disulfide bridge by Cys oxidation |
| •Different Sequence Inter-Disulfide bridge by Cys oxidation |
| •Oxidation between Se-Cys |
| •Amide Cyclic (end) |
| •Amide Cyclic (side chain) by Lys |
| •Amide Cyclic (side chain) by Orn |
■ 熒光/染料標記
| •Biotin- |
| •FITC- |
| •Dansyl- |
| •Lys (Dnp) |
| •DeThioBiotin |
| •-ED-FITC |
| •-EDDansyl |
| •D-Lys (Dnp) |
| •-EDBiotin |
| •-Lys (FITC)- |
| •-Lys (Dansyl)- |
| •Dab (Dnp) |
| •Glu (Biotin-PEG2) |
| •-Lys (FITC) |
| •-Lys (Dansyl) |
| •Dap (Dnp) |
| •-Lys (Biotin)- |
| •Lys (Ahx-FITC) |
| •Dansli-e-Lys |
| •-EDDnp |
| •-Lys (Biotin) |
| •FITC-e-Lys |
| •Dansyl-Ahx- |
| •-Lys (LC-Biotin)- |
| •FITC-Ahx- |
| •5-FAM- |
| •-Lys (LC-Biotin) |
| •5-TAMRA- |
| •5,6-FAM |
| •Biotin-e-Lys |
| •5 (6)-TAMTA- |
| •6’FAM |
| •Lys (S-S-Biotin) |
| •-EDYAMRA |
| •-ED-5-FAM |
| •Biotin-Ahx- |
| •-Lys (TAMRA)- |
| •-Lys (5-FAM)- |
| •Orn (Bio) |
| •-Lys (5-TAMRA) |
| •Lys (5,6-FAM) |
| •MCA- |
| •5-TAMRA-e-Lys |
| •-Lys (5-FAM) |
| •-Lys (MCA)- |
| •5-TAMRA-Acp |
| •5-FAM-E-Lys |
| •-Lys (MCA) |
| •5-FAM-Ahx- |
| •Lys (MCA)- |
■ BSA、KLH、OVA 偶聯(lián)
| •BSA-Peptide N terminus |
| •KLH-Peptide N terminus |
| •OVA-Peptide N terminus |
| •BSA-Peptide C terminus |
| •KLH-Peptide C terminus |
| •OVA-Peptide C terminus |
| •BSA-Peptide via Cys |
| •KLH-Peptide via Cys |
| •OVA-Peptide via Cys |
■ Phe & Tyr 衍生物
| •D-2-Cl-Phe |
| •D-4-F-Phe |
| •L-2-Me-Phe |
| •L-3-I-Tyr |
| •L-2-Cl-Phe |
| •L-4-F-Phe |
| •D-4-Me-Phe |
| •D-3,5-DiI-Tyr |
| •D-3-Cl-Phe |
| •D-4-NO2-Phe |
| •L-4-Me-Phe |
| •L-3,5-DiI-Tyr |
| •L-3-Cl-Phe |
| •L-4-NO2-Phe |
| •D-4-NH2-Phe |
| •D-3-NO2-Tyr |
| •D-4-Cl-Phe |
| •D-4-I-Phe |
| •L-4-NH2-Phe |
| •L-3-NO2-Tyr |
| •L-4-Cl-Phe |
| •L-4-I-Phe |
| •D-3-Cl-Tyr |
| •D-3,5-DiNO2-Tyr |
| •D-3,4-DiCl-Phe |
| •D-3-CN-Phe |
| •L-3-Cl-Tyr |
| •L-3,5-DiNO2-Tyr |
| •L-3,4-DiCl-Phe |
| •L-3-CN-Phe |
| •D-3,5-DiCl-Tyr |
| •L-3-F-Tyr |
| •D-4-Br-Phe |
| •D-4-CN-Phe |
| •L-3,5-DiCl-Tyr |
| •L-4-NO2-Phg |
| •L-4-Br-Phe |
| •L-4-CN-Phe |
| •D-3,5-DiBr-Tyr |
| •D-4-NO2-Phg |
| •D-3-F-Phe |
| •D-2-Me-Phe |
| •L-3,5-DiBr-Tyr |
| •L-3,5-DiF-Phe |
| •L-3-F-Phe |
| •D-3-I-Tyr |
■ Linker
| •Gly |
| •Ava |
| •AEA |
| •GABA |
| •Beta-Ala |
| •Ahx |
| •Ado |
| •Mini-PEG |
| •Mini-PEG2 |
| •Mini-PEG3 |
| •PEG4 |
■ 樹脂
| •peptide on Wang Resin |
| •peptide on 2-CTC Resin |
| •peptide on Rink Amide AM Resin |
| •peptide on Rink Amide MBHA Resin |
■ D 型氨基酸
| •D-Ala |
| •D-Lys |
| •D-Glu |
| •D-Tyr |
| •D-Arg |
| •D-Met |
| •D-Gln |
| •D-Thr |
| •D-Asp |
| •D-Pro |
| •D-His |
| •D-Trp |
| •D-Asn |
| •D-Phe |
| •D-Leu |
| •D-Val |
| •D-Cys |
| •D-Ser |
■ 同型氨基酸
| •Har |
| •HomoCit |
| •beta-HomoMet |
| •beta-HomoSer |
| •D-Har |
| •D-HomoCit |
| •beta-HomoPro |
| •beta-HomoThr |
| •Hcy |
| •HomoLeu |
| •beta-HomoVal |
| •beta-HomoTrp |
| •HPh |
| •HomoPro |
| •beta-HomoAsp |
| •beta-HomoTyr |
| •D-HPh |
| •D-HomoPro |
| •beta-HomoAsn |
| •Azidohomoalanine |
| •Hse |
| •beta-HomoIle |
| •beta-HomoGlu |
| •beta-HomoAla |
| •D-Hse |
| •beta-HomoLeu |
| •beta-HomoGln |
| •beta-HomoPhe |
■ 特殊氨基酸
| •beta-Asp |
| •3-Thi |
| •D-Chg |
| •Cys (pMeBzl) |
| •D-beta-Asp |
| •Aib |
| •Ac6c |
| •Cys (pMeOBzl) |
| •gamma-Glu |
| •Abu |
| •Dab |
| •Oic |
| •D- gamma-Glu |
| •D-Abu |
| •Dap |
| •Tic |
| •Cys (Cam) |
| •Hyp |
| •Pra |
| •D-Tic |
| •D-Cys (Cam) |
| •Phg |
| •D-Pra |
| •Cys (Bzl) |
| •Cys (Acm) |
| •D-Phg |
| •Allo-Thr |
| •Epsilon-Lys |
| •Cys (tBu) |
| •Nva |
| •D-Allo-Thr |
| •D-Epsilon-Lys |
| •Cys (StBu) |
| •D-Nva |
| •Gly (allyl) |
| •5-ASA |
| •Met (O) |
| •Nle |
| •D-Gly (allyl) |
| •Bpa |
| •D-Met (O) |
| •D-Nle |
| •Cys (Pyrene-maleimide) |
| •Pip |
| •Cys (SNO) |
| •Cit |
| •D-1-Nal |
| •Nip |
| •Met (O)2 |
| •D-Cit |
| •L-1-Nal |
| •2-Aze |
| •D-Met (O)2 |
| •Orn |
| •D-2-Nal |
| •3-Aze |
| •Lys (Ac) |
| •D-Orn |
| •L-2-Nal |
| •[Psi (CH2NH)] |
| •Ac-Lys |
| •Pen |
| •D-2-Pal |
| •[CS-NH] |
| •Lys (Dde) |
| •D-Pen |
| •L-2-Pal |
| •Se-Met |
| •Tle |
| •Cpg |
| •D-3-Pal |
| •Se-Cys |
| •Ser (Octanoic acid) |
| •Cha |
| •L-3-pal |
| •DOPA |
| •Ser (Lipoic acid) |
| •D-Cha |
| •D-4-Pal |
| •isoGln |
| •D-Ser (Octanoic acid) |
| •Chg |
| •L-4-Pal |
| •D-isoGln |
| •Arg (Boc2) |
| •Asp-OMe |
| •D-Glu (OtBu) |
| •Lys (Z) |
| •Arg (NO2) |
| •Asp-OtBu |
| •Gln (Trt) |
| •Ser (Bzl) |
| •Arg (Z2) |
| •Asn (Trt) |
| •His (Boc) |
| •Ser (Trt) |
| •Arg (pbf) |
| •Cys (MMt) |
| •His (Trt) |
| •Ser (tBu) |
| •D-Arg (pdf) |
| •Cys (Trt) |
| •Tyr (propargyl) |
| •Tyr (tBu) |
| •Asp (Oall) |
| •D-Cys (Trt) |
| •Lys (Boc) |
| •Asp (OBn) |
| •Glu (Oall) |
| •Lys (DMT) |
| •D-Tyr (tBu) |
| •Asp (OBzl) |
| •Glu (OBzl) |
| •Lys (Fomc) |
| •Thr (tBu) |
| •Asp (OMe) |
| •Glu (OMe) |
| •Lys (Mtt) |
| •Trp (Boc) |
| •Asp (OtBu) |
| •Glu (OtBu) |
| •Lys (Trt) |
| •Trp (Farnesyl) |
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